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Products >  Protein_Research >  Protease_Inhibition >  Calpastatin

Calpain Inhibitor: Calpastatin Protease Inhibitor

Calpastatin is an endogenous protease inhibitor that acts specifically on calpain (a calcium-dependent cysteine protease). It contains four repetitive calpain inhibition sequences spanning 120 to 140 amino acid residues (domains I, II, and IV) and an N-terminal non-homologous sequence (domain L). The product consists of highly purified recombinant human calpastatin domain I.

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Applications

  • Calpain protease inhibition

Source

Recombinant Human Calpastatin Domain I

Purity

Homogeneous on SDS-polyacrylamide gel electrophoresis. Greater than 90% pure as determined by amino acid composition analysis.

Storage

–20°C

Properties

Molecular weight:14 kDa
Peptide length:137 a.a.

Typical Activity: 50 nM of calpastatin domain I completely inhibits the activity of 7.5 µg/mL calpain I. 15 nM of calpastatin domain I inhibits 50% of the activity of 7.5 µg/mL calpain I.

Form

Lyophilized white powder

References

  1. Uemori, T. et al. (1990) Biochem. Biophys. Res. Comm. 166:1485.
  2. Asada, K. et al. (1989) J. Enz. Inhib. 3:49.
  3. Kanaki, R. and Murachi, T. (1987) Protein, Nucleic Acid and Enzyme 32:116 (Japanese Journal).



 
 
Products
Cat. # Product Contents Size Price Units Select
7316 Calpastatin 3 mg $214.00
 

 

 
 

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