The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL, and the c-MPL gene product was named thrombopoietin receptor (TPOR). It is also known as MPLV, CD110, hlb219, and THCYT2. TPOR possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. TPOR-deficient mice are severely thrombocytopenic, suggesting an important role for TPOR in megakaryocyte and platelet formation.
These products are affinity-purified IgG antibodies (Cat.# 10401) and biotinylated antibodies (Cat.# 10403) that recognize mouse TPOR. The antibodies were raised in rat using a recombinant protein, and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FC) detection of mouse TPOR protein.
