Angiotensinogen (also known as serpin peptidase inhibitor, clade A, member 8) is a protein implicated in controlling blood pressure. It is an essential component of the renin-angiotensin system (RAS). In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-I. Angiotensin-I is further cleaved by angiotensin-converting enzyme (ACE) to yield the physiologically active peptide angiotensin-II. Angiotensin II is also implicated in regulation of insulin-like growth factor 1 (IGF-1) expression. Urinary excretion of angiotensinogen in a rat model of hypertension was shown to be a marker of intrarenal RAS activity.
These kits are solid-phase sandwich ELISAs using two antibodies that are highly specific to human, mouse, or rat angiotensinogen protein; one is precoated on the ELISA plate and the other is HRP-conjugated. These kits can be used to measure human, mouse, or rat angiotensinogen in serum, EDTA-plasma, urine or cell culture media.