Endothelins are among the most potent vasoconstrictor proteins known. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta. The active form of endothelin-3 is a ligand for endothelin receptor type B (EDNRB). This interaction is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in the endothelin-3 gene are associated with the congenital disorders Hirschsprung disease (HSCR) and Waardenburg syndrome (WS). Endothelin-3 is also known as PPET3, HSCR4, and WS4B.
This product is an affinity-purified IgG antibody that recognizes human, mouse, and rat ET-3. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of ET-3.
