Anti-Human NP95 (mt40) Mouse IgG MoAb

Human nucleoprotein 95 (NP95) is a member of a subfamily of RING-finger type E3 ubiquitin ligases and is encoded by the UHRF1 gene in humans. NP95 binds specifically to DNA and recruits a histone deacetylase to regulate gene expression. NP95 expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma (Rb) gene expression. NP95 also functions in the p53-dependent response to DNA damage, and its expression is upregulated in lymphomas induced by radiation. NP95 is also known as ubiquitin-like with PHD and ring finger domains 1 (UHRF1), ubiquitin-like PHD and RING finger domain-containing protein 1, RING finger protein 106 (RNF106), inverted CCAAT box-binding protein of 90 kDa (ICBP90), nuclear zinc finger protein Np95, E3 ubiquitin-protein ligase UHRF1, hUHRF1, hNP95, HuNp95, and FLJ21925.