Claudins are a family of proteins that control the flow of molecules in the intercellular space between epithelial cells. They are the most important components of tight junctions--a form of cell-to-cell adhesion that forms continuous seals around cells. Tight junctions act as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Claudins have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Over 24 members of the claudin family have been identified in humans. In mouse, claudin-1, -2, -6, -7, and -15 are expressed at high levels in liver and kidney, while claudin-5 is expressed in vascular endothelial cells. Differential expression of the human CLDN7 gene has been associated with breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, and thyroid cancer. Claudin-7 is expressed constitutively in the mammary epithelium throughout development, and is essential for NaCl homeostasis in distal nephrons. It is also known as clostridium perfringens enterotoxin receptor-like 2 (CPETRL2) and CEPTRL2.
This product is an affinity-purified IgG antibody that recognizes mouse/rat claudin-7 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, and immunocytochemical (ICC) detection of mouse/rat claudin-7 protein.
