Claudins are integral membrane proteins and components of tight junction strands, which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Tight junction strands also play critical roles in maintaining cell polarity and signal transductions. In humans, 24 claudin superfamily members have been identified. Claudin 6 is essential for blastocyst formation in preimplantation mouse embryos, and for the formation and maintenance of the epidermal permeability barrier. It is also known as skullin and AL024037. Claudin-6 has been identified as a novel diagnostic marker for primitive germ cell tumors, and other tumors with primitive phenotypes. Expression of claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas.
This product is an affinity-purified IgG antibody that recognizes human claudin-6 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human claudin-6 protein.