Anti-Human TEK/Tie-2 (2A1) Mouse IgG MoAb

The endothelial tyrosine kinase TEK is a cell-surface receptor that binds the growth factor angiopoietin-1. It is closely related to the TIE receptor tyrosine kinase. TEK-mediated signaling regulates angiogenesis, reorganization of the actin cytoskeleton, and survival, proliferation, migration, adhesion, and spreading of endothelial cells. Activation of TEK leads to downstream activation of MAPK1/ERK2 and MAPK3/ERK1 kinases. Mutations in the TEK gene are associated with inherited venous malformations. TEK is also known as TEK tyrosine kinase, endothelial; endothelial tyrosine kinase, Tunica interna endothelial cell kinase, tyrosine kinase with Ig and EGF homology domains-2 (TIE-2), hTIE2, p140 TEK, CD202b, angiopoietin-1 receptor, VMCM, and VMCM1.