Anti-Human Galectin-3 Mouse IgG MoAb

Galectin-3 is a member of the lectin family of carbohydrate-binding proteins. In humans, it is encoded by the LGALS3 gene, and is approximately 30 kDa in size. Galectin-3 has a N-terminal proline-rich tandem repeat domain, which allows it to self-associate, and a single C-terminal carbohydrate recognition domain. It binds beta-galactoside and IgE, and is involved in a broad range of functions, including apoptosis, innate immunity, cell adhesion, chemoattraction, cell growth and differentiation, and T-cell regulation. Galectin-3 expression is implicated in processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. Elevated levels of galectin-3 are also associated with cancer and inflammation. Galectin-3 is also known as lectin, galactoside-binding, soluble, 3; carbohydrate-binding protein 35, galactose-specific lectin 3, laminin-binding protein, lectin L-29, Mac-2 antigen, IgE-binding protein, L31, GAL3, MAC2, CBP35, GALBP, GALIG, and LGALS2.