Metabolism in mammalian cells requires a constant supply of glucose. Since glucose is a hydrophilic molecule, it must be transported across the cell membrane by dedicated proteins, known as glucose transporters. In humans, these proteins are encoded by the facilitative glucose transporter (GLUT) gene family, now known as the solute carrier family 2 or SLC2A gene family. GLUT3 is expressed in, and is the main transporter for, neuronal cells. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells, and carcinoma cell lines. GLUT3 has both a higher affinity for glucose and at least a fivefold greater transport capacity than GLUT1, GLUT2, and GLUT4. GLUT3 is also known as solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3); and glucose transporter type 3, brain.
This product is an affinity-purified IgG antibody that recognizes human GLUT3 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human GLUT3 protein.
