The 14-3-3 family of conserved regulatory proteins is expressed in all eukaryotic cells and are encoded by seven genes in mammals. 14-3-3 proteins bind many types of signaling proteins, including kinases, phosphatases, and transmembrane receptors. More than 100 signaling proteins have been reported as 14-3-3 ligands. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. Elevated amounts of 14-3-3 proteins are found in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. The 14-3-3-gamma protein is 100% identical to the rat ortholog. It is also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide and YWHAG. Expression of 14-3-3-gamma protein is induced by growth factors in human vascular smooth muscle cells, and is elevated in skeletal and heart muscles. It also interacts with RAF1, a serine/threonine protein kinase, and protein kinase C.
These products are affinity-purified IgG antibodies that recognize human 14-3-3-gamma protein. The antibodies were raised in rabbit (Cat.# 18647) or mouse (Cat.# 10037) using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human 14-3-3-gamma protein.
