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Products >  IBL >  Alzheimers_Disease >  Antibodies >  sAPP_Beta_Human

Anti-Human sAPP-beta Wild Type Rabbit IgG Antibody

The accumulation of amyloid beta protein in the cerebral cortex in Alzheimer's disease (AD) is only one of the outcomes of proteolytic cleavage of amyloid precursor protein (APP). More than 50 different mutations in the APP gene can cause early-onset Alzheimer disease. Cleavage by beta- and gamma-secretase (amyloidogenic pathway) leads to production of amyloid-beta and soluble APP-beta, while cleavage by alpha-secretase (nonamyloidogenic pathway) results in a soluble form of APP, sAPP-alpha. Several mutations in the APP gene can give rise to variants of both sAPP-alpha and sAPP-beta.

This product is an affinity-purified IgG antibody that recognizes the wild-type (wt) human sAPP-beta protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunoprecipitation (IP) of human sAPP-beta.
At-A-Glance Documents Images & Data

Features

  • Cat.#: 18957A, 18957B
  • Target Name: Human sAPP-beta-wt
  • Antigen: Human sAPP-beta-wt C-terminal synthetic peptide
  • Application: WB, IP
  • Specificity: Does not cross-react with sAPP-alpha or full-length APP
  • Target Entrez Gene ID: 351

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically)

  • Western blot: 2 µg/mL
  • Immunoprecipitation: 3 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTF-gamma


 
 
Products
New Cat. # Product Package Size Price # of Units Select
18957B Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 100 ug $499.00
18957A Anti-Human sAPP beta-Wild Type Rabbit IgG Affinity Purify 10 ug $100.00
 

 


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