Apolipoprotein E (ApoE) is a main apoprotein of the chylomicron--lipoprotein particles that contain triglycerides, phospholipids, cholesterol, and proteins. It is also known as Apo-E, AD2, LPG, and LDLCQ5. Three isoforms of ApoE are produced by alternative splicing: ApoE2, ApoE3, and ApoE4. The primary role of ApoE is to transport lipoproteins, fat-soluble vitamins, and cholesterol into the lymph and then into the blood. Normal functioning of ApoE is essential to prevent the accumulation of cholesterol and triglycerides in the blood. ApoE expression is highest in the liver, but has also been found in other tissues such as the brain, kidneys, spleen, and nervous system. The ApoE receptor belongs to the highly conserved low density lipoprotein (LDL) receptor gene family; seven mammalian ApoE receptors have been identified. Mutations in the APOE gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III). Recent studies have implicated roles for ApoE in processes that are not directly related to lipid transport, including Alzheimer's disease (AD), immunoregulation, and cognitive function.
This product is an affinity-purified IgG antibody that recognizes human ApoE protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human ApoE protein.
