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Products >  Cell_Biology >  mTOR_Signaling >  Antibodies >  mTOR_Monoclonal

Anti-mTOR (N5D11) Mouse IgG MoAb

Rapamycin (also known as sirolimus) is an immunosuppressant drug that is commonly used to prevent organ rejection after transplantation. It prevents activation of T cells and B cells by inhibiting their response to interleukin-2 (IL-2). Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates cell growth, motility, and survival in response to nutrient levels, as well as transcription and protein synthesis. Rapamycin inhibits mTOR activity by associating with the mTOR receptor, FKB12. mTOR functions as part of two complexes with distinct composition and cellular functions, known as mTORC1 and mTORC2. mTOR is also known as mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin associated protein (FRAP), FKBP12-rapamycin complex-associated protein 1 (FRAP1), FK506 binding protein 12-rapamycin associated protein 2 (FRAP2), rapamycin and FKBP12 target 1 (RAFT1), rapamycin target protein 1 (RAPT1), and FLJ44809.

This product is an affinity-purified IgG antibody that recognizes rat and human mTOR protein. The antibody was raised in mouse using recombinant rat mTOR protein, and can be used for Western blot (WB) detection or immunoprecipitation (IP) of rat and human mTOR protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 10343A, 10343B
  • Target Name: Rat mTOR protein
  • Antigen: Rat mTOR recombinant protein
  • Specificity: Reacts with recombinant and native rat and human mTOR
  • Application: WB, IP
  • Target Entrez Gene ID: 56718

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL
  • Immunoprecipitation: 3–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin associated protein, FRAP, FKBP12-rapamycin complex-associated protein 1, FRAP1, FK506 binding protein 12-rapamycin associated protein 2, FRAP2, rapamycin and FKBP12 target 1, RAFT1, rapamycin target protein 1, RAPT1, FLJ44809




 
 
Products
Cat. # Product Package Size Price # of Units Select
10343A Anti-mTOR (N5D11) Mouse IgG MoAb 10 ug $113.00 *
10343B Anti-mTOR (N5D11) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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