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Products >  Cell_Biology >  Virus_Research >  Retrovirus >  OX40_OX40L

Monoclonal Antibodies for detecting OX40 and OX40L

OX40 (CD134) and OX40L (CD252) are members of the tumor necrosis factor (TNF) superfamily of receptors and ligands, respectively. OX40 is expressed on activated lymphocytes, and signaling through OX40 generates strong costimulatory effects, including T cell proliferation, cytokine production, and T cell migration into tissues. These responses are mediated by OX40L expressed on antigen presenting cells, such as dendritic cells and activated B cells. Both OX40 and OX40L are constitutively expressed in human T cell leukemia virus type I (HTLV-I)-infected T cells. OX40 surface expression has been shown to be induced by a HTLV-I-encoded protein (Tax).

These monoclonal antibodies recognize either OX40 or OX40L. The antibodies were generated in mouse and can be used for detection of OX40 or OX40L by Western blot, immunoprecipitation, or flow cytometry.

At-A-Glance Documents

Features

Cat. # 10909A, 10909B

  • Target Name: OX40
  • Antigen: Recombinant soluble OX40
  • Clone: B7-B5
  • Application: WB, IP, FCM
  • Entrez Gene ID: 22163

Cat. # 10913A, 10913B

  • Target Name: OX40
  • Antigen: Recombinant soluble OX40
  • Clone: B#11
  • Application: WB, IP, FCM
  • Entrez Gene ID: 22163

Cat. # 10915A

  • Target Name: OX40L
  • Antigen: Lysate of HTLV-1 persistently-infected cell line (MT-2)
  • Clone: TAG34
  • Application: WB, IP, FCM
  • Entrez Gene ID: 7292

Cat. # 10917A, 10917B

  • Target Name: OX40L
  • Antigen: Lysate of HTLV-1 persistently-infected cell line (MT-2)
  • Clone: 8F4
  • Application: WB, IP, FCM
  • Entrez Gene ID: 7292

Applications

 Recommended antibody concentration (the optimal concentration should be determined empirically)

  • Western blot: 10 µg/mL
  • Immunoprecipitation: 10 µg
  • FCM: 1 µg/1x105 cells

Storage

Lyophilized product, 5 years at 2 - 8°C
Solution, 2 years at –20°C

Form

Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3

Alternative Names

OX40: Tnfrsf4; ACT35; CD134; Ly-70; Txgp1; TXGP1L
OX40L: TNFSF4, GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L




 
 
Products
Cat. # Product Package Size Price # of Units Select
10909A Anti-CD134/OX40 (B7-B5) Mouse IgG MoAb 100 ug $965.00
10909B Anti-CD134/OX40 (B7-B5) Mouse IgG MoAb 500 ug $1,500.00
10913A Anti-CD134/OX40 (B#11) Mouse IgG MoAb 100 ug $965.00
10913B Anti-CD134/OX40 (B#11) Mouse IgG MoAb 500 ug $1,500.00
10915A Anti-CD252/OX40L (TAG34) Mouse IgG MoAb 100 ug $965.00
10917A Anti-CD252/OX40L (8F4) Mouse IgG MoAb 100 ug $965.00
10917B Anti-CD252/OX40L (8F4) Mouse IgG MoAb 500 ug $1,500.00
 

 


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