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Products >  Cell_Biology >  Miscellaneous >  Viral_Detection >  Influenza_Virus

Influenza Virus (Human)

Influenza virus is classified into three groups, A, B, and C by the difference of nuclear protein. Prevalent types of Influenza virus are H1, H3 and B strain. The structure of Influenza virus is shown below. Influenza virus is further classified into subtypes by the difference of Neuraminidase (NA) and Haemagglutinin (HA) that are the surface glycoprotein of the virus. H1N1 subtype and H3N2 subtype are known they cause severe febrile illness. A virus particle consists of a head region and a stem region. A head region has a receptor domain to the target cell and in stem region there is a special amino acid sequence that is necessary to fuse the virus and the target cell.
At-A-Glance Documents Images & Data Resources

Applications

  • Clones C179, F49, C111, 9D6 can be used for Influenza Virus Detection and Typing
  • The Polyclonal Antibody can be used for Detection of both Influenza A and B Virus
  • Clones C179, F49, C111, 9D6 and the Polyclonal Antibody can be used for immunohistochemical Staining by the PAP (peroxidade-antiperoxidase) Staining Method
  • Clone C179 can be used for Neutralization Activity Test of Influenza Virus H1N1 and H2N2
  • Clone C179 can be used in Experiments to Protect Animals Against Influenza Virus Infection
  • Clone C111, 9D6 can be used for Western Blotting Analysis

Source

Clone Immun. Immun. host Sub-
class		 Antib titer
C179 Influenza A virus A/Okuda/57 strain (H2N2) BALB/c mouse IgG2a 1:2,000
F49 Influenza A virus A2/Aichi2/68/ strain (H3N2) BALB/c mouse IgG1 1:2,000
C111 Influenza A virus A/Okuda/57 strain (H2N2) BALB/c mouse IgG2a 1:2,000
9D6 Influenza B virus B/Nagasaki/1/87 strain BALB/c mouse IgG1 1:2,000
Polyclonal Vaccine mixture of influenza
A/Peking/262/95(H1N1),
A/Wuhan/395/95(H3N2), B/Mie/1/93 and
B/Guandong/05/94 		Rabbit

Storage

Lyophilized antibodies are stable at 4°C for 2 years. The reconstituted solution should be stored in aliquots at –20°C.

Notes

For research use only. Not for use in diagnostic or therapeutic procedures.

Form

Lyophilized.

Monoclonal (Cat.# M145, M146, M147, M148)

 Dissolve in 50 µL of distilled water
(final conc.: 2.0 mg/mL, not containing any preservative)
Polyclonal (Cat.# M149)

 Dissolve in 200 µL of distilled water
(final conc.: 2.0 mg/mL, not containing any preservative)

Specificity

Anti-Human Influenza A (H1N1, H2N2)

  • This antibody specifically recognizes the highly conserved HA Stem epitope in H1N1 and H2N2 viruses.
  • This antibody does not cross react with HA in H3N2 subtype of Influenza A virus.
  • Refer to the table for titers of monoclonal antibodies against Influenza virus.
  • This antibody has H1N1 and H2N2 virus neutralization activity.
  • This antibody does not affect the results of the haemagglutination inhibition test for all viruses.

Anti-Human Influenza A (H3N2)

  • This antibody specifically recognizes the HA stem region in H3N2 subtype of Influenza A virus.
  • This antibody does not cross react with HA in H1N1 and H2N2 subtypes of Influenza A virus.
  • Refer to the table for titers of monoclonal antibodies against influenza virus.
  • This antibody cross-reacts A/duck/Czechoslovakia/1/56 (H4N6) and A/chicken/Germany "N"/49 (H10N7) besides human virus.
  • This antibody has no effect on haemagglutination inhibition test for all subtypes of virus.

Anti-Human Influenza A (H1, H2, H3)

  • This antibody specifically recognizes the membrane protein in all subtypes of Influenza A virus, H1N1, H2N2 and H3N2.
  • Refer to the table for titers of monoclonal antibodies against influenza virus.

Anti-Human Influenza B

  • This antibody specifically recognizes the nuclear protein (NP) of Influenza B virus.
  • Refer to the table for titers of monoclonal antibodies against influenza B virus.

Polyclonal antibody to Human Influenza A, B

  • It was confirmed that this antibody reacts with Influenza A/PR/8/34 (H1N1), A/Aichi/2/68 (H3N2) and B/Nagaski/1/87. It is assumed that this antibody should react with both Influenza A and B virus to the same extent.



 
 
Products
Cat. # Product Package Size Price License # of Units Select
M145 Monoclonal Anti-Human Influenza A (H1N1, H2N2) (Clone C179) 0.1 mg $276.00 License Statements
M146 Monoclonal Anti-Human Influenza A (H3N2) (Clone F49) 0.1 mg $276.00 License Statements
M148 Monoclonal Anti-Human Influenza B (Clone 9D6) 0.1 mg $276.00  
M147 Monoclonal Anti-Influenza A (H1, H2, H3) (Clone C111) 0.1 mg $276.00  
M149 Polyclonal Antibody to Human Influenza A, B (Rabbit Polyclonal) 0.4 mg $221.00  
 

 


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