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Products >  Cell_Biology >  Miscellaneous >  Primary_Antibodies_H-N >  MDMX_Human_Monoclonal

Anti-Human MDMX (77A1) Mouse IgG MoAb

The MDM4 gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus. It is the human homolog of mouse double minute 4 (MDM4) protein and shows structural similarity to p53-binding protein MDM2. MDM4 is also called Mdm4 p53 binding protein homolog (mouse); transformed 3T3 cell double minute 4, p53 binding protein (mouse); MDMX, Mdm2-like p53-binding protein, HDMX, MRP1, MDM4-related protein 1, double minute 4 protein, and p53-binding protein Mdm4. Both MDM4 and MDM2 bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, MDM4 inhibits p53 by binding its transcription activation domain. MDM4 can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 activity.

This product is an affinity-purified IgG antibody that recognizes human MDM4/MDMX protein. The antibody was raised in mouse using recombinant MDM4/MDMX protein, and can be used for Western blot (WB) detection of human MDM4/MDMX protein.

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Features

  • Cat.#: 10201A, 10201B
  • Target Name: Human MDM4/MDMX protein
  • Antigen: Human MDM4/MDMX recombinant protein
  • Application: WB
  • Target Entrez Gene ID: 4194

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Mdm4 p53 binding protein homolog (mouse); transformed 3T3 cell double minute 4, p53 binding protein (mouse); MDMX, Mdm2-like p53-binding protein, HDMX, MRP1, MDM4-related protein 1, double minute 4 protein, p53-binding protein Mdm4




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
10201A Anti-Human MDMX (77A1) Mouse IgG MoAb 10 ug $113.00 *
  10201B Anti-Human MDMX (77A1) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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