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Products >  Cell_Biology >  Miscellaneous >  Primary_Antibodies_H-N >  MDA5_Human

Anti-Human MDA5 Rabbit IgG Antibody

Interferon induced with helicase C domain 1 (IFIH1) protein is a member of a group of RNA helicases, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), known as DEAD box proteins. IFIH1 is also known as melanoma differentiation-associated protein 5 (MDA5), clinically amyopathic dermatomyositis autoantigen 140 kDa, helicase with 2 CARD domains (HLCD), helicard, murabutide down-regulated protein, RIG-I-like receptor 2 (RLR-2), CADM-140 autoantigen, RNA helicase-DEAD box protein 116 (RH116), DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, and IDDM19. IFIH1/MDA5 plays a major role in sensing viral infection and in the activation of a cascade of antiviral and inflammatory responses. IFIH1 gene expression is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Treatment with both these agents causes irreversible reprogramming of melanomas, while treatment with either agent alone only achieves reversible differentiation. Mutations in the IFIH1 gene are associated with diabetes mellitus insulin-dependent, type 19.

This product is an affinity-purified IgG antibody that recognizes human IFIH1/MDA5 protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human IFIH1/MDA5 protein.

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Features

  • Cat.#: 29020A
  • Target Name: Human IFIH1/MDA5 protein
  • Antigen: Human IFIH1/MDA5 N-terminal synthetic peptide
  • Specificity: Reacts with human and mouse IFIH1/MDA5
  • Application: WB
  • Target Entrez Gene ID: 64135

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Melanoma differentiation-associated protein 5, MDA5, clinically amyopathic dermatomyositis autoantigen 140 kDa, helicase with 2 CARD domains, HLCD, helicard, murabutide down-regulated protein, RIG-I-like receptor 2, RLR-2, CADM-140 autoantigen, RNA helicase-DEAD box protein 116, RH116, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, IDDM19




 
 
Products
Cat. # Product Contents Size Price Units Select
29020A Anti-Human MDA5 Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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