The human fragile histidine triad (FHIT) gene encodes a protein that is involved in purine metabolism. Aberrant transcripts from this gene, typically from carcinogen-induced damage and translocations, have been found in about half of all esophageal, stomach, and colon carcinomas. Although the exact function of human FHIT protein is not known, animal studies have demonstrated its role as a tumor suppressor in breast and lung cancers. FHIT protein is also known as bis(5'-adenosyl)-triphosphatase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, AP3A hydrolase, AP3Aase, dinucleosidetriphosphatase, and FRA3B.
This product is an affinity-purified IgG antibody that recognizes human FHIT protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human FHIT protein.