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Products >  Cell_Biology >  Miscellaneous >  Primary_Antibodies_A_D >  c-MPL_TPOR_Mouse_Monoclonal

Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG Antibody

The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL, and the c-MPL gene product was named thrombopoietin receptor (TPOR). It is also known as MPLV, CD110, hlb219, and THCYT2. TPOR possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. TPOR-deficient mice are severely thrombocytopenic, suggesting an important role for TPOR in megakaryocyte and platelet formation.

These products are affinity-purified IgG antibodies (Cat.# 10401) and biotinylated antibodies (Cat.# 10403) that recognize mouse TPOR. The antibodies were raised in rat using a recombinant protein, and can be used for Western blot (WB) detection, immunoprecipitation (IP), or flow cytometry (FC) detection of mouse TPOR protein.

  At-A-Glance   Documents

Features

  • Cat.#: 10401A, 10401B
  • Target Name: Mouse TPOR
  • Antigen: Mouse TPOR (extracellular domain) recombinant protein
  • Application: WB, IP, FC
  • Target Entrez Gene ID: 17480

  • Cat.#: 10403A, 10403B
  • Target Name: Mouse TPOR
  • Antigen: Mouse TPOR (extracellular domain) recombinant protein
  • Note: Biotinylated antibody
  • Application: WB, IP, FC
  • Target Entrez Gene ID: 17480

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–2 µg/mL (Cat.# 10401); 0.5–2.0 µg/mL (Cat.# 10403)
  • Immunoprecipitation: 1–2 µg/mL (Cat.# 10401); 0.5–2.0 µg/mL (Cat.# 10403)
  • Flow cytometry: 1 µg per reaction

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

TPOR, MPLV, CD110, hlb219, THCYT2




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
10401A Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb 10 ug $113.00 *
  10401B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb 100 ug $499.00
  10403A Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 5 ug $113.00 *
  10403B Anti-Mouse c-MPL/TPOR (AMM2) Rat IgG MoAb Biotin 50 ug $499.00
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