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Products >  Cell_Biology >  Miscellaneous >  Primary_Antibodies_A_D >  c-MPL-P_Human

Anti-Human c-MPL-P (M617) Rabbit IgG Antibody

The human c-MPL oncogene was identified as the human homolog of the murine myeloproliferative leukemia (MPL) virus oncogene, v-MPL. c-MPL encodes a protein with homology to members of the hematopoietic receptor superfamily. It is also known as MPLV, TPOR, CD110, and THCYT2. The protein thrombopoietin, a major regulator of megakaryocytopoiesis and platelet formation, was subsequently identified as the ligand for c-MPL. The protein encoded by the c-MPL gene (CD110) possesses two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. This protein exists as two alternatively spliced isoforms: c-MPL-P (wild type) and c-MPL-K (truncated). Antisense oligodeoxynucleotides of c-MPL have been shown to inhibit megakaryocyte colony formation. CD110-deficient mice are severely thrombocytopenic, suggesting an important role for CD110 in megakaryocyte and platelet formation.

This product is an affinity-purified IgG antibody that recognizes human c-MPL-P protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection of human c-MPL-P protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18505A, 18505B
  • Target Name: Human c-MPL-P protein
  • Antigen: Human c-MPL-P C-terminal synthetic peptide
  • Application: WB
  • Specificity: Human c-MPL-P; cross-reacts with UT-7/thrombopoietin
  • Target Entrez Gene ID: 4352

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

MPLV, TPOR, CD110, THCYT2




 
 
Products
Cat. # Product Package Size Price # of Units Select
18505A Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 25 ug $113.00 *
18505B Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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