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Products >  Cell_Biology >  Miscellaneous >  Primary_Antibodies_A_D >  ALK_Mouse_Monoclonal

Anti-Mouse ALK (mAb 16-39) Rat IgG Antibody

Anaplastic lymphoma kinase (ALK) is a receptor type tyrosine kinase that belongs to the insulin receptor superfamily. It is also known as anaplastic lymphoma receptor tyrosine kinase, Tcrz, CD246, and NBLST3. ALK is expressed in the central and peripheral nervous system at late embryonic stage, and plays an important role in brain development. The ALK gene is rearranged, mutated, or amplified in various tumors, including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. This monoclonal antibody (clone mAb16-39) elicits tyrosine phosphorylation of ALK in human neuroblastoma (SK-N-SH) cells. It also induces further phosphorylation of signal transfer molecules like insulin receptor substrate-1 (IRD-1).

This product is an affinity-purified IgG antibody that recognizes mouse ALK protein. The antibody was raised in rat using a recombinant protein, and can be used for Western blot (WB) detection or immunoprecipitation (IP) of mouse ALK protein.

At-A-Glance Documents

Features

  • Cat.#: 10373B
  • Target Name: Mouse ALK protein
  • Antigen: Recombinant mouse ALK protein (extracellular domain)
  • Application: WB, IP
  • Specificity: Cross-reacts with human ALK
  • Target Entrez Gene ID: 11682

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 micro;g/mL).

Alternative names

Anaplastic lymphoma receptor tyrosine kinase, Tcrz, CD246, NBLST3




 
 
Products
Cat. # Product Package Size Price # of Units Select
10373B Anti-Mouse ALK (mAb 16-39) Rat IgG MoAb 100 ug $499.00
 

 



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