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Cell Biology


Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Rab27A-B

Anti-Rab27A/B Rabbit IgG Antibody

Rab27 is a member of the Rab subfamily of Ras GTPase proteins. Rab27 protein is membrane-bound and is post-translationally modified by the addition of geranylgeranyl groups on two C-terminal cysteines. Two isoforms of Rab27 are known, encoded by the RAB27A and RAB27B genes. Rab27A and Rab27B were found to control different steps of the exosome secretion pathway. Rab27 proteins are involved in melanosome transport in melanocytes and in killing activity in cytotoxic T lymphocytes. In addition, they have been suggested to play roles in protein transport and small GTPase-mediated signal transduction. Mutations in the RAB27A gene are associated with Griscelli syndrome type 2, a disease characterized by hypopigmentation and immunodeficiency. Rab27A is also known as RAB27A, member RAS oncogene family; GTP-binding protein Ram, RAB27, GS2, RAM, and HsT18676. Rab27B is also known as RAB27B, member RAS oncogene family; and C25KG2.

These products are affinity-purified IgG antibodies that recognize human, mouse, and rat Rab27A or Rab27B proteins. The antibodies were raised in rabbit using recombinant Rab27B protein and can be used for Western blot (WB) detection of Rab27A or Rab27B proteins.

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Features

  • Cat.#: 18973A
  • Target Name: Human Rab27B protein
  • Antigen: Human Rab27B recombinant protein
  • Specificity: Cross-reacts with mouse and rat Rab27B; does not cross-react with Rab3 proteins
  • Application: WB
  • Target Entrez Gene ID: 5874

  • Cat.#: 18975A
  • Target Name: Human Rab27B protein
  • Antigen: Human Rab27B recombinant protein
  • Specificity: Cross-reacts with mouse and rat Rab27A and Rab27B; does not cross-react with Rab3 proteins
  • Application: WB
  • Target Entrez Gene ID: 5874

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3.To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Rab27A: RAB27A, member RAS oncogene family; GTP-binding protein Ram, RAB27, GS2, RAM, HsT18676

Rab27B: RAB27B, member RAS oncogene family; C25KG2




 
 
Products
Cat. # Product Contents Size Price Units Select
18973A Anti-Rab27B Rabbit IgG Affinity Purify 100 ug $499.00
18975A Anti-Rab27A/B Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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