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Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Leptin

Anti-Leptin (C) Rabbit IgG Antibody

Leptin is an adipose-derived hormone that acts through a signaling pathway to regulate energy (food) intake and expenditure, maintaining steady levels of adipose tissue mass. Leptin was discovered in studies of obesity in mice. In humans, leptin is a 16 kDa protein, encoded by the LEP gene, and is expressed mostly in white adipose tissue. Leptin acts through the leptin receptor, which exists as multiple isoforms. In addition to its role in adipose tissue, leptin regulates immune and inflammatory responses, hematopoiesis, angiogenesis, and wound healing. Mutations in the LEP gene cause severe to morbid obesity and hypogonadism, and are associated with the development of type 2 diabetes. Leptin is also known as obesity protein (OB), obesity factor, OBS, and LEPD.

These products are affinity-purified IgG antibodies that recognize human, mouse, or rat leptin protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection of leptin protein.

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Features

  • Cat.#: 18545A
  • Target Name: Human leptin protein
  • Antigen: Human leptin C-terminal synthetic peptide
  • Specificity: Cross-reacts with mouse and rat leptin
  • Application: WB
  • Target Entrez Gene ID: 3952

  • Cat.#: 18546A
  • Target Name: Rat leptin protein
  • Antigen: Rat leptin C-terminal synthetic peptide
  • Specificity: Cross-reacts with mouse leptin
  • Application: WB
  • Target Entrez Gene ID: 25608

  • Cat.#: 18547A
  • Target Name: Mouse leptin protein
  • Antigen: Mouse leptin C-terminal synthetic peptide
  • Specificity: Cross-reacts with rat leptin
  • Application: WB
  • Target Entrez Gene ID: 16846

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

Obesity protein, OB, obesity factor, OBS, LEPD




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18545A Anti-Human Leptin (C) Rabbit IgG Affinity Purify 100 ug $499.00
  18546A Anti-Rat Leptin (C) Rabbit IgG Affinity Purify 100 ug $499.00
  18547A Anti-Mouse Leptin (C) Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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