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Cell Biology


Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Insulin-Mouse_Polyclonal

Insulin C Antibody

Insulin is produced in a step-wise process. Preproinsulin is a biologically inactive precursor that consists of an N-terminal signal peptide followed by the proinsulin molecule. Removal of the signal peptide by signal peptidases results in proinsulin alone. Proinsulin contains the A-chain, B-chain and a 31-amino-acid Connecting peptide or C-peptide. The C-peptide is positioned between the A-chain and the B-chain and functions to connect them. The C-peptide is removed once proinsulin is processed into insulin.

Antibodies to the proinsulin C-peptide (also known as insulin C) are frequently used to study the structure, function and metabolism of insulin as well as proinsulin. Insulin C antibodies can also be used for immunocytochemistry and for immunohistochemical studies of paraffin-embedded or frozen tissue sections. The following insulin C antibodies are available:

  • Mouse insulin C polyclonal antibody is generated in guinea pig immunized with the KLH-conjugated mouse insulin C-peptide (71-84) [SPGDLQTLALEVAR].
  • Human insulin C monoclonal antibody is generated in mouse immunized with the KLH-conjugated human insulin C-peptide (71–86) [GPGAGSLQPLALEGSL].
  • Mouse insulin C monoclonal antibody is generated in rat immunized with the KLH-conjugated mouse insulin C-peptide (71–84) [SPGDLQTLALEVAR].

  At-A-Glance   Documents   Images & Data

Applications

  • Structural, functional and metabolic analyses of proinsulin and insulin
  • Immunocytochemistry
  • Immunohistochemistry of paraffin-embedded or frozen tissue sections

 

Storage

Lyophilized antibody is stable at 4°C for up to 2 years. The reconstituted solution can be stored at 4°C for up to 6 months or at –20°C for up to 1 year.

Notes

For research use only. Not for clinical diagnostics.

Specificity

  • Anti-Mouse Insulin C, Polyclonal (Cat. No. M178):
    This product does not cross-react with human C-peptide.
  • Anti-Human Insulin C, Monoclonal (Clone 1B1) (Cat. No. M232):
    This product does not cross-react with human insulin A- and B-chains, mouse C-peptide, or rat C-peptide.
  • Anti-Mouse Insulin C, Monoclonal (Clone 1J) (Cat. No. M233):
    This product does not cross-react with mouse insulin A- and B-chains, human C-peptide, or rat C-peptide.

Form

Lyophilized

Reconstitution

Dissolve the lyophilized antibody in 50 µl of distilled water (final concentration: 2.0 mg/ml).




 
 
Products
New Offers Cat. # Product Contents Size Price Units Select
M232 Anti-Human Insulin C, Monoclonal (Clone h-Ins 1B-1) 0.1 mg $357.00
M233 Anti-Mouse Insulin C, Monoclonal (Clone M-Ins 1J-4) 0.1 mg $357.00
  M178 Anti-Mouse Insulin C, Polyclonal 0.1 mg $357.00
 

 

 
 

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