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Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Endothelin_15-21

Anti-Endothelin (15-21) (C) Rabbit IgG Antibody

Endothelins are among the most potent vasoconstrictor proteins known. Overexpression of endothelins contributes to hypertension and heart disease. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta. Endothelin-1 is also known as PPET1 and HDLCQ7; endothelin-2 is also known as PPET2; endothelin-3 is also known as PPET3, HSCR4, and WS4B.

This product is an affinity-purified IgG antibody that recognizes human ET-1, ET-2, and ET-3. The antibody was raised in rabbit using a synthetic peptide, and can be used for immunohistochemical (IHC) detection of human endothelins.

  At-A-Glance   Documents

Features

  • Cat.#: 18204A
  • Target Name: Human ET-1, ET-2, ET-3
  • Antigen: Human endothelin (15-21) C-terminal synthetic peptide
  • Application: IHC
  • Specificity: Reacts with human ET-1, ET-2, ET-3
  • Target Entrez Gene ID: 1906, 1907, 1908

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 3–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

ET-1: PPET1, HDLCQ7; ET-2: PPET2; ET-3: PPET3, HSCR4, WS4B




 
 
Products
Cat. # Product Contents Size Price Units Select
18204A Anti-Endothelin (15-21) (C) Rabbit IgG Affinity Purify 50 ug $499.00
 

 

 
 

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