Takara
login | register | order now | view cart | feedback
Products
Cell Biology


Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Endothelin-B_Receptor_Human

Anti-Human Endothelin-B Receptor Antibody

Endothelins are among the most potent vasoconstrictor proteins known. They are expressed in many tissues and mediate their activity through binding to two distinct endothelin receptors, known as endothelin A receptor and endothelin B receptor. The endothelin B receptor, encoded by the EDNRB gene, associates with guanine-nucleotide-binding (G) proteins; this interaction activates a phosphatidylinositol-calcium second messenger system. Endothelin B receptor binds endothelin-1 and endothelin-3 with high affinity. It is expressed in endothelial cells lining the wall of all blood vessels, and in lung, brain, and heart. Mutations in the EDRNB gene are linked to Waardenburg syndrome and Hirschsprung disease type 2. The endothelin B receptor is also known as endothelin receptor type B, ET-B, ETBR, ETRB, hET-BR, HSCR, HSCR2, ABCDS, and endothelin receptor nonselective type.

These products are affinity-purified IgG antibodies that recognize human endothelin B receptor. The antibodies was raised in rabbit (Cat.# 16205) or mouse (Cat.# 10253) using a synthetic peptide or recombinant protein, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of endothelin B receptor.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 10253A, 10253B
  • Target Name: Human endothelin B receptor
  • Antigen: Human endothelin B receptor recombinant protein (expressed in Sf9 cells)
  • Application: WB, IHC
  • Target Entrez Gene ID: 1910

  • Cat.#: 16205B
  • Target Name: Human endothelin B receptor
  • Antigen: Human endothelin B receptor N-terminal synthetic peptide
  • Application: WB
  • Specificity: Cross-reacts with bovine and rat endothelin B receptor
  • Target Entrez Gene ID: 1910

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL (Cat.# 10253); 2–10 µg/mL (Cat.# 16205)
  • Immunohistochemical techniques: 5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

endothelin receptor type B, ET-B, ETBR, ETRB, hET-BR, HSCR, HSCR2, ABCDS, endothelin receptor nonselective type




 
 
Products
Cat. # Product Package Size Price # of Units Select
10253A Anti-Human Endothelin-B Receptor (8Z11) Mouse IgG MoAb 10 ug $113.00 *
10253B Anti-Human Endothelin-B Receptor (8Z11) Mouse IgG MoAb 100 ug $499.00
16205B Anti-Human Endothelin-B Receptor (B27) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


Clontech is a Takara Bio Company © 2014 Privacy Policy | Terms & Conditions