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Cell Biology

Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Endothelin-B_Receptor_Human

Anti-Human Endothelin-B Receptor Antibody

Endothelins are among the most potent vasoconstrictor proteins known. They are expressed in many tissues and mediate their activity through binding to two distinct endothelin receptors, known as endothelin A receptor and endothelin B receptor. The endothelin B receptor, encoded by the EDNRB gene, associates with guanine-nucleotide-binding (G) proteins; this interaction activates a phosphatidylinositol-calcium second messenger system. Endothelin B receptor binds endothelin-1 and endothelin-3 with high affinity. It is expressed in endothelial cells lining the wall of all blood vessels, and in lung, brain, and heart. Mutations in the EDRNB gene are linked to Waardenburg syndrome and Hirschsprung disease type 2. The endothelin B receptor is also known as endothelin receptor type B, ET-B, ETBR, ETRB, hET-BR, HSCR, HSCR2, ABCDS, and endothelin receptor nonselective type.

These products are affinity-purified IgG antibodies that recognize human endothelin B receptor. The antibodies was raised in rabbit (Cat.# 16205) or mouse (Cat.# 10253) using a synthetic peptide or recombinant protein, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of endothelin B receptor.

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  • Cat.#: 10253A, 10253B
  • Target Name: Human endothelin B receptor
  • Antigen: Human endothelin B receptor recombinant protein (expressed in Sf9 cells)
  • Application: WB, IHC
  • Target Entrez Gene ID: 1910

  • Cat.#: 16205B
  • Target Name: Human endothelin B receptor
  • Antigen: Human endothelin B receptor N-terminal synthetic peptide
  • Application: WB
  • Specificity: Cross-reacts with bovine and rat endothelin B receptor
  • Target Entrez Gene ID: 1910


Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL (Cat.# 10253); 2–10 µg/mL (Cat.# 16205)
  • Immunohistochemical techniques: 5 µg/mL


Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.


Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

endothelin receptor type B, ET-B, ETBR, ETRB, hET-BR, HSCR, HSCR2, ABCDS, endothelin receptor nonselective type

Offers Cat. # Product Contents Size Price Units Select
10253A Anti-Human Endothelin-B Receptor (8Z11) Mouse IgG MoAb 10 ug $113.00 *
  10253B Anti-Human Endothelin-B Receptor (8Z11) Mouse IgG MoAb 100 ug $499.00
  16205B Anti-Human Endothelin-B Receptor (B27) Rabbit IgG Affinity Purify 100 ug $499.00
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