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Cell Biology

Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Endothelin-3

Anti-Endothelin-3 Rabbit IgG Antibody

Endothelins are among the most potent vasoconstrictor proteins known. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta. The active form of endothelin-3 is a ligand for endothelin receptor type B (EDNRB). This interaction is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in the endothelin-3 gene are associated with the congenital disorders Hirschsprung disease (HSCR) and Waardenburg syndrome (WS). Endothelin-3 is also known as PPET3, HSCR4, and WS4B.

This product is an affinity-purified IgG antibody that recognizes human, mouse, and rat ET-3. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of ET-3.

  At-A-Glance   Documents


  • Cat.#: 18202A, 18203B
  • Target Name: Human ET-3
  • Antigen: ET-3 synthetic peptide
  • Application: WB, IHC
  • Specificity: Reacts with human, mouse, and rat ET-3 and big ET-3; shows 0.8% cross-reactivity with ET-1 and ET-2
  • Target Entrez Gene ID: 1908


Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL
  • Immunohistochemical techniques: 3–5 µg/mL


Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.


Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 50 µg/mL)

Alternative names


Cat. # Product Contents Size Price Units Select
18202A Anti-Endothelin-3 Rabbit IgG Affinity Purify 5 ug $113.00
18202B Anti-Endothelin-3 Rabbit IgG Affinity Purify 50 ug $499.00



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