Endothelins are among the most potent vasoconstrictor proteins known. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta. Endothelin-1 is a potent vasoconstrictor, produced by vascular endothelial cells. Overexpression of endothelin-1 contributes to hypertension and heart disease, and also has effects on the central nervous system. Endothelin-1 is also known as PPET1 and HDLCQ7.
This product is an affinity-purified IgG antibody that recognizes human, bovine, canine, mouse, porcine, and rat ET-1. The antibody was raised in rabbit using a synthetic peptide, and can be used for immunohistochemical (IHC) detection of ET-1.