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Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Endothelin-1

Anti-Endothelin-1 Rabbit IgG Antibody

Endothelins are among the most potent vasoconstrictor proteins known. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta. Endothelin-1 is a potent vasoconstrictor, produced by vascular endothelial cells. Overexpression of endothelin-1 contributes to hypertension and heart disease, and also has effects on the central nervous system. Endothelin-1 is also known as PPET1 and HDLCQ7.

This product is an affinity-purified IgG antibody that recognizes human, bovine, canine, mouse, porcine, and rat ET-1. The antibody was raised in rabbit using a synthetic peptide, and can be used for immunohistochemical (IHC) detection of ET-1.

  At-A-Glance   Documents

Features

  • Cat.#: 18201A
  • Target Name: ET-1
  • Antigen: ET-1 synthetic peptide (common to human, bovine, canine, mouse, porcine, rat ET-1)
  • Application: IHC
  • Specificity: Reacts with ET-1 and big ET-1; shows 0.2%–1.0% cross-reactivity with ET-2 and ET-3
  • Target Entrez Gene ID: 1906

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 3–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

PPET1, HDLCQ7




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18201A Anti-Endothelin-1 Rabbit IgG Affinity Purify 50 ug $499.00
 

 

 
 

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