Endothelins are among the most potent vasoconstrictor proteins known. Overexpression of endothelins contributes to hypertension and heart disease. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta.
These products are affinity-purified IgG antibodies that recognizes human and rat big ET-1. The antibodies were raised in rabbit using synthetic big ET-1 (22-38) peptides, and can be used for immunohistochemical (IHC) detection of human or rat big ET-1 protein.