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Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Big_Endothelin-1

Big Endothelin-1 (22-38) Rabbit IgG Antibody

Endothelins are among the most potent vasoconstrictor proteins known. Overexpression of endothelins contributes to hypertension and heart disease. Three isoforms are known, each containing 21 amino acids: endothelin-1 (ET-1), endothelin-2 (ET-2), and endothelin-3 (ET-3). All three isoforms are encoded by a 38-amino-acid precursor known as big endothelin. Endothelins are expressed in many tissues, including lung, kidney, brain, pituitary, and placenta.

These products are affinity-purified IgG antibodies that recognizes human and rat big ET-1. The antibodies were raised in rabbit using synthetic big ET-1 (22-38) peptides, and can be used for immunohistochemical (IHC) detection of human or rat big ET-1 protein.

  At-A-Glance   Documents

Features

  • Cat.#: 18203A, 18203B
  • Target Name: Human big ET-1 protein
  • Antigen: Human big ET-1 (22-38) synthetic peptide
  • Application: IHC
  • Specificity: Does not cross-react with other endothelin isoforms
  • Target Entrez Gene ID: 1906

  • Cat.#: 18205A
  • Target Name: Rat big ET-1 protein
  • Antigen: Rat big ET-1 (22-38) synthetic peptide
  • Application: IHC
  • Specificity: Does not cross-react with other endothelin isoforms; cross-reacts with human big ET-1
  • Target Entrez Gene ID: 1906

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 3–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration, 100 µg/mL).

Alternative names

preproendothelin-1, ET1, PPET1, HDLCQ7




 
 
Products
Cat. # Product Contents Size Price Units Select
18203A Anti-Human Big Endothelin-1 (22-38) Rabbit IgG Affinity Purify 5 ug $113.00 *
18203B Anti-Human Big Endothelin-1 (22-38) Rabbit IgG Affinity Purify 50 ug $499.00
18205A Anti-Rat Big Endothelin-1 (22-38) Rabbit IgG Affinity Purify 50 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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