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Products >  Cell_Biology >  Metabolic_Diseases >  Antibodies >  Angiotensinogen

Anti-Angiotensinogen Antibody

Angiotensinogen (also known as serpin peptidase inhibitor, clade A, member 8; Serpin A8, Ang, Ang II, PAT, and ANRT) is a protein implicated in controlling blood pressure. It is an essential component of the renin-angiotensin system (RAS). In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-I. Angiotensin-I is further cleaved by angiotensin-converting enzyme (ACE) to yield the physiologically active peptide angiotensin-II. Angiotensin II is also implicated in regulation of insulin-like growth factor 1 (IGF-1) expression. Urinary excretion of angiotensinogen in a rat model of hypertension was shown to be a marker of intrarenal RAS activity.

These products are affinity-purified antibodies that recognize either mouse/rat or human angiotensinogen protein. The antibodies can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of angiotensinogen protein.

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Features

  • Cat.#: 28101A, 28101B
  • Target Name: Mouse/rat angiotensinogen protein
  • Antigen: Mouse angiotensinogen C-terminal synthetic peptide
  • Application: WB, IHC
  • Specificity: Reacts with mouse and rat angiotensinogen
  • Target Entrez Gene ID: 11606, 24179
  • Cat.#: 10417A, 10417B
  • Target Name: Human angiotensinogen protein
  • Antigen: Recombinant human angiotensinogen protein
  • Application: WB
  • Specificity: Recognizes the C-terminus of human angiotensinogen (394-485 aa)
  • Target Entrez Gene ID: 183

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL (Cat.# 28101A, 28101B); 1 µg/mL (Cat.# 10417A, 10417B)
  • Immunohistochemical techniques: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute with H2O (final concentration 100 µg/mL).

Alternative names

Serpin peptidase inhibitor, clade A, member 8; Serpin A8, Ang, AngII, PAT, ANRT




 
 
Products
Cat. # Product Contents Size Price Units Select
10417A Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb 10 ug $114.00 *
10417B Anti-Human Angiotensinogen (104AT 601.2.80) Mouse IgG MoAb 100 ug $525.00
28101A Anti-Mouse/Rat Angiotensinogen (405) Rabbit IgG Affinity Purify 10 ug $113.00 *
28101B Anti-Mouse/Rat Angiotensinogen (405) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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