Angiotensinogen (also known as serpin peptidase inhibitor, clade A, member 8; Serpin A8, Ang, Ang II, PAT, and ANRT) is a protein implicated in controlling blood pressure. It is an essential component of the renin-angiotensin system (RAS). In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-I. Angiotensin-I is further cleaved by angiotensin-converting enzyme (ACE) to yield the physiologically active peptide angiotensin-II. Angiotensin II is also implicated in regulation of insulin-like growth factor 1 (IGF-1) expression. Urinary excretion of angiotensinogen in a rat model of hypertension was shown to be a marker of intrarenal RAS activity.
These products are affinity-purified antibodies that recognize either mouse/rat or human angiotensinogen protein. The antibodies can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of angiotensinogen protein.