Anti-Human Adiponectin Receptor 2 Antibody is an affinity-purified IgG antibody that recognizes the human adiponectin receptor 2 (ADIPOR2) protein. The antibody was raised in rabbit using a synthetic peptide and can be detected through Western blot analysis of human ADIPOR2 protein.
Human adiponectin is a protein hormone secreted by adipocytes and is involved in several metabolic functions, including the regulation of glucose levels and fatty acid metabolism. Two receptors for adiponectin have been identified with homology to the G protein-coupled receptors (GPCRs): ADIPOR1 and ADIPOR2. Similar to GPCRs, ADIPOR2 also possesses seven transmembrane domains. However, ADIPOR2 is not known to associate with G proteins. Binding of adiponectin to ADIPOR2 mediates increased AMP-activated protein kinase (AMPK) activity, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) ligand activity, fatty acid oxidation, and glucose uptake. ADIPOR2 is also known as progestin and adipoQ receptor family member II (PAQR2), and ACDCR2.