Anti-Adiponectin Receptor 1 Antibody is an affinity-purified IgG antibody that recognizes human adiponectin receptor 1 (ADIPOR1) protein. The anti-adiponectin antibody was raised in rabbit using a synthetic peptide and can be used in Western blot analysis and detection of the human ADIPOR1 protein.
Human adiponectin is a protein hormone secreted by adipocytes that is involved in several metabolic functions, including the regulation of glucose levels and fatty acid metabolism. Two receptors for adiponectin have been identified that share homology with the G protein-coupled receptors (GPCRs): adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2). Similar to GPCRs, ADIPOR1 possesses seven transmembrane domains; however, ADIPOR1 has not been reported to associate with G proteins. Binding of adiponectin to ADIPOR1 results in activation of an AMP-dependent kinase (AMPK) signaling pathway that regulates fatty acid oxidation and insulin sensitivity. ADIPOR1 is also known as progestin and adipoQ receptor family member I (PAQR1), CGI45, ACDCR1 and TESBP1A.