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Products >  Cell_Biology >  Epigenetics >  Antibodies >  Sir2_SIRT1_Human

Anti-Human Sir2/SIRT1 (Silent Information Regulator 2) Rabbit IgG Antibody

Sirtuin 1, encoded by the SIRT1 gene in humans, is a member of a protein family that is homologous to yeast Sir2 protein. Sirtuins are grouped into four classes, with sirtuin 1 belonging to class 1. The functions of human sirtuins are not known; however, they are thought to be intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. In yeast, sirtuin 1 exhibits histone deacetylase activity. Induction of sirtuin 1 gene expression in mice increases insulin sensitivity, suggesting a role in management of type 2 diabetes. Sirtuin 1 is also known as sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; SIR2L1, hSIR2, hSIRT1, SIR2-like protein 1, SIR2alpha, NAD-dependent deacetylase sirtuin-1, sir2-like 1, and sirtuin type 1.

This product is an affinity-purified IgG antibody that recognizes human sirtuin 1 protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human sirtuin 1 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18761A, 18761B
  • Target Name: Human sirtuin 1 protein
  • Antigen: Human sirtuin 1 C-terminal synthetic peptide
  • Application: WB, IHC, IP
  • Target Entrez Gene ID: 23411

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 3 µg/mL
  • Immunohistochemical techniques: 5 µg/mL
  • Immunoprecipitation: 3 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3.To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

Sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; SIRT1, SIR2L1, hSIR2, hSIRT1, SIR2-like protein 1, SIR2alpha, NAD-dependent deacetylase sirtuin-1, sir2-like 1, sirtuin type 1




 
 
Products
Cat. # Product Package Size Price # of Units Select
18761A Anti-Human Sir2/SIRT1(Silent information Regulator 2) Rabbit IgG Affinity Purify 10 ug $113.00 *
18761B Anti-Human Sir2/SIRT1(Silent information Regulator 2) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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