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Products >  Cell_Biology >  Epigenetics >  Antibodies >  OGG1_Human_Monoclonal

Anti-Human OGG1 (7E2) Mouse IgG MoAb

8-oxoguanine DNA glycosylase (OGG1) is found in many species and catalyzes the excision of 8-oxoguanine from DNA. This modified base byproduct occurs as a result of exposure to reactive oxygen species. Alternative splicing of the C-terminal region of the OGG1 gene in humans results in two major groups of variants: type 1 and type 2. Both groups share a common N-terminal region that contains a mitochondrial targeting sequence required for OGG1 localization in mitochondria. Although knockout mice lacking the OGG1 gene were observed to have a normal lifespan, the precise role of OGG1 in mutagenesis and cancer remains controversial. OGG1 is also known as 8-hydroxyguanine DNA glycosylase, DNA-apurinic or apyrimidinic site lyase, AP lyase, N-glycosylase/DNA lyase, HMMH, MMH, MUTM, OGH1, and HOGG1.

This product is an affinity-purified IgG antibody that recognizes human OGG1 protein. The antibody was raised in mouse using recombinant OGG1 and can be used for Western blot (WB) detection of human OGG1 protein.

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Features

  • Cat.#: 10171A, 10171B
  • Target Name: Human OGG1 protein
  • Antigen: Human OGG1 recombinant protein
  • Application: WB
  • Target Entrez Gene ID: 4968

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

8-hydroxyguanine DNA glycosylase, DNA-apurinic or apyrimidinic site lyase, AP lyase, N-glycosylase/DNA lyase, HMMH, MMH, MUTM, OGH1, HOGG1




 
 
Products
Cat. # Product Contents Size Price Units Select
10171A Anti-Human OGG1 (7E2) Mouse IgG MoAb 10 ug $113.00 *
10171B Anti-Human OGG1 (7E2) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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