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Products >  Cell_Biology >  Epigenetics >  Antibodies >  MBD3_Human_Monoclonal

Anti-Human MBD3 Mouse IgG MoAb

DNA methylation, a major epigenetic modification of eukaryotic genomes, is essential to mammalian development. A family of nuclear proteins, characterized by the presence of a methyl-CpG binding domain (MBD), has been identified as interacting with methylated DNA. Unlike other family members, methyl-CpG binding domain protein 3 (MBD3) is incapable of binding to DNA. The predicted MBD3 protein sequence shares 71% and 94% identity with human MBD2 (isoform 1) and mouse Mbd3, respectively. MBD3 is part of a multisubunit complex that contains nucleosome remodeling and histone deacetylase activities. MBD3 is known to mediate the interaction of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.

This product is an affinity-purified IgG antibody that recognizes human MBD3 protein. The antibody was raised in mouse using a synthetic peptide, and can be used for Western blot (WB) detection of human MBD3 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 10281A, 10281B
  • Target Name: Human MBD3 protein
  • Antigen: Human MBD3 C-terminal synthetic peptide
  • Specificity: Does not cross-react with MBD2
  • Application: WB
  • Target Entrez Gene ID: 53615

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 0.1 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.




 
 
Products
Cat. # Product Package Size Price # of Units Select
10281A Anti-Human MBD3 (3A3) Mouse IgG MoAb 10 ug $113.00 *
10281B Anti-Human MBD3 (3A3) Mouse IgG MoAb 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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