The DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA, and can be classified into three groups, depending on the position of methylation on the DNA base. In mammals, DNA methylation serves a wide variety functions, including development, regulation of gene expression, genomic imprinting, and epigenetic modifications. Three active DNA methyltransferases have been identified in mammals, DNMT1, DNMT3A, and DNMT3B. DNMT1 plays a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. It is also known as DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, m.HsaI, AIM, MCMT, CXXC-type zinc finger protein 9 (CXXC9), and HSN1E. Defects in DNMT1 are associated with some tumors and developmental abnormalities. Inactivation of the DNMT1 gene in mouse embryos is lethal.
This product is an affinity-purified IgG antibody that recognizes human DNMT1. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human DNMT1.