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Products >  Cell_Biology >  Epigenetics >  Antibodies >  DNMT-1_Human

Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG Antibody

The DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA, and can be classified into three groups, depending on the position of methylation on the DNA base. In mammals, DNA methylation serves a wide variety functions, including development, regulation of gene expression, genomic imprinting, and epigenetic modifications. Three active DNA methyltransferases have been identified in mammals, DNMT1, DNMT3A, and DNMT3B. DNMT1 plays a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. It is also known as DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, m.HsaI, AIM, MCMT, CXXC-type zinc finger protein 9 (CXXC9), and HSN1E. Defects in DNMT1 are associated with some tumors and developmental abnormalities. Inactivation of the DNMT1 gene in mouse embryos is lethal.

This product is an affinity-purified IgG antibody that recognizes human DNMT1. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human DNMT1.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18871A, 18871B
  • Target Name: Human DNMT1
  • Antigen: Human DNMT1 C-terminal synthetic peptide
  • Application: WB
  • Target Entrez Gene ID: 1786

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

DNA (cytosine-5-)-methyltransferase 1, DNA methyltransferase HsaI, DNA MTase HsaI, m.HsaI, AIM, MCMT, CXXC-type zinc finger protein 9, CXXC9, HSN1E




 
 
Products
Cat. # Product Package Size Price # of Units Select
18871A Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG AffinityPurify 10 ug $113.00 *
18871B Anti-Human DNMT-1 (DNA Methyltransferase-1) Rabbit IgG AffinityPurify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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