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Products >  Cell_Biology >  Cytokines >  Antibodies_H-T >  TPO_Human

Anti-Human TPO Rabbit IgG Antibody

Thrombopoietin is a glycoprotein hormone encoded by the THPO gene in humans. It is required for the maturation and proliferation of megakaryocytes in bone marrow, as well as for thrombopoiesis. It is also known as megakaryocyte growth and development factor (MGDF), megakaryocyte colony-stimulating factor (MKCSF), megakaryocyte stimulating factor, myeloproliferative leukemia virus oncogene ligand, ML, TPO, MPLLG, THCYT1, C-mpl ligand, and MPL ligand. Thrombopoietin is produced mainly in the liver and kidney. Due to its role in megakaryocyte differentiation, thrombopoietin has been proposed as the major physiological regulator of circulating platelets. Mutations in the THPO gene are linked to development of thrombocythemia, a myeloproliferative disorder characterized by overproduction of platelets.

This product is an affinity-purified IgG antibody that recognizes human thrombopoietin protein. The antibody was raised in rabbit using a synthetic peptide and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human thrombopoietin protein.

At-A-Glance Documents

Features

  • Cat.#: 18501A, 18501B
  • Target Name: Human thrombopoietin protein
  • Antigen: Human thrombopoietin N-terminal synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 7066

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL
  • Immunohistochemical techniques: 2–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

THPO, megakaryocyte growth and development factor, MGDF, megakaryocyte colony-stimulating factor, MKCSF, megakaryocyte stimulating factor, myeloproliferative leukemia virus oncogene ligand, ML, TPO, MPLLG, THCYT1, C-mpl ligand, MPL ligand




 
 
Products
Cat. # Product Package Size Price # of Units Select
18501A Anti-Human TPO Rabbit IgG Affinity Purify 25 ug $113.00 *
18501B Anti-Human TPO Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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