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Products >  Cell_Biology >  Cytokines >  Antibodies_H-T >  NFkappB_p65_Human

Anti-Human NF-kappaB p65 Rabbit IgG Antibody

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) is a ubiquitous transcription factor that was identified based on its interaction with an 11-base pair sequence in the immunoglobulin light-chain enhancer in B cells. NF-kappaB is involved in a variety of signaling processes, including responses to stress, cytokines, free radicals, ultraviolet radiation, and bacterial and viral antigens. NF-kappaB consists of two subunits, each of which can exist as multiple isoforms. In humans, a 65 kDa protein encoded by the RELA gene contributes to the most abundant form of NF-kappaB: a heterodimer of RELA/p65 and another subunit, p50. NF-kappaB p65 interacts with many other transcription factors, and contains a transactivation domain in its C-terminus. The inhibitor of NF-kappaB activity, I-kappaB, exerts its effect mostly through interaction with p65. NF-kappaB p65 is also known as v-rel reticuloendotheliosis viral oncogene homolog A (avian), NFKB3, NFKB-p65, NF-kappa-B p65delta3, transcription factor p65, and nuclear factor NF-kappa-B p65 subunit.

These products are affinity-purified IgG antibodies that recognize human NF-kappaB p65 protein. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of NF-kappaB p65 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18665A, 18665B
  • Target Name: Human NF-kappaB p65 protein
  • Antigen: Human NF-kappaB p65 N-terminal synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 5970

  • Cat.#: 18667A, 18667B
  • Target Name: Human NF-kappaB p65 protein
  • Antigen: Human NF-kappaB p65 C-terminal synthetic peptide
  • Application: WB, IHC
  • Target Entrez Gene ID: 5970

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–5 µg/mL
  • Immunoprecipitation: 5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

RELA, v-rel reticuloendotheliosis viral oncogene homolog A (avian), NFKB3, NFKB-p65, NF-kappa-B p65delta3, transcription factor p65, nuclear factor NF-kappa-B p65 subunit




 
 
Products
Cat. # Product Package Size Price # of Units Select
18665A Anti-Human NFkappaB p65 (N) Rabbit IgG Affinity Purify 10 ug $100.00
18665B Anti-Human NFkappaB p65 (N) Rabbit IgG Affinity Purify 100 ug $499.00
18667A Anti-Human NFkappaB p65 (C) Rabbit IgG Affinity Purify 10 ug $100.00
18667B Anti-Human NFkappaB p65 (C) Rabbit IgG Affinity Purify 100 ug $499.00
 

 



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