KC (CXCL1) Rabbit IgG Antibody is an affinity-purified IgG antibody that recognizes mouse keratinocyte chemoattractant (KC) or C-X-C motif chemokine 1 (CXCL1) protein. The anti-mouse KC antibody is raised in rabbit using recombinant KC protein or synthetic peptides and is applicable in Western blot (WB) or immunohistochemical (IHC) detection of mouse KC protein.
Mouse keratinocyte chemoattractant (KC) or C-X-C motif chemokine 1 (CXCL1) was originally identified by overexpression in murine keratinocytes, monocytes, and macrophages following stimulation by platelet-derived growth factor (PDGF) and macrophage colony-stimulating factor (M-CSF). The murine KC gene is homologous to human chemokine C-X-C motif ligand 1 (CXCL1), previously called growth-regulated alpha protein or GRO-alpha or rat CINC-1. Mouse KC is also called CXCL1, C-X-C motif chemokine 1, SCYB1, Fsp and melanoma growth stimulating activity (MSGA). A truncated form of KC, designated KC-T, exhibits dramatically increased biological activities has been described under the name HSF (hematopoietic synergistic factor). KC is involved in chemotaxis and cell activation of neutrophils and monocytes/macrophages. The synthesis of KC in vascular endothelial cells is induced by thrombin. The murine KC receptor is homologous to the interleukin 8 (IL-8) type B receptor. The KC receptor is capable of binding both KC and macrophage inflammatory protein-2 (MIP-2) with high affinity. Studies have shown that KC expression decreases the severity of multiple sclerosis, suggesting that KC may have a neuroprotective function.