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Products >  Cell_Biology >  Cytokines >  Antibodies_H-T >  JAB_SOCS-1_Human

Anti-Human JAB/SOCS-1 (J192) Rabbit IgG Antibody

Suppressor of cytokine signaling 1 (SOCS-1) protein, encoded by the SOCS1 gene, is a member of the STAT-induced STAT inhibitor (SSI) family. SOCS-1 protein can bind to, and inhibit the activity of, kinases that are involved in the JAK/STAT signaling pathway. SOCS1 gene expression is induced by IL2, IL3, erythropoietin, GM-CSF, and interferon (IFN) gamma. In addition to JAK2, SOCS-1 interacts with growth hormone receptor, CD117, colony stimulating factor 1 (CSF1) receptor, and tyrosine-protein kinase Tec. Knockout studies in mice suggested a role for SOCS-1 as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. SOCS-1 is also known as STAT-induced STAT inhibitor 1 (SSI-1), JAK binding protein (JAB), cytokine-inducible SH2 protein 1 (CIS1), CISH-1, and Tec-interacting protein 3 (TIP-3).

This product is an affinity-purified IgG antibody that recognizes human SOCS-1. The antibody was raised in mouse using a synthetic peptide. It can be used for Western blot (WB) detection of human SOCS-1 protein.

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Features

  • Cat.#: 18381A, 18381B
  • Target Name: Human SOCS-1 protein
  • Antigen: Human SOCS-1 C-terminal synthetic peptide
  • Application: WB
  • Specificity: Cross-reacts with mouse SOCS-1
  • Target Entrez Gene ID: 8651

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.




 
 
Products
Offers Cat. # Product Contents Size Price Units Select
18381A Anti-Human JAB/SOCS-1 (J192) Rabbit IgG Affinity Purify 10 ug $113.00 *
  18381B Anti-Human JAB/SOCS-1 (J192) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 

 
 

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