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Products >  Cell_Biology >  Cytokines >  Antibodies_H-T >  IkappaB-alpha_Human

Anti-Human IkappaB-alpha (I037) Rabbit IgG Antibody

The transcription factor NF-kappaB is found in almost all animal cell types and is involved in a variety of regulatory processes. IkappaB-alpha is one member of a class of proteins that inhibit the action of NF-kappaB. IkappaB-alpha masks the nuclear localization signals (NLS) of NF-kappaB protein and keeps it sequestered in an inactive state in the cytoplasm. It also blocks the binding of NF-kappaB to DNA. IkappaB-alpha is also known to interact with REL dimers to inhibit NF-kappaB/REL complexes that are involved in inflammatory responses. Mutations in the NFKBIA gene that encodes IkappaB-alpha are associated with Hodgkin's lymphoma and some types of T-cell immunodeficiency syndromes. IkappaB-alpha is also known as nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (NFKBIA), NF-kappa-B inhibitor alpha, IKBA, MAD-3, and NFKBI.

This product is an affinity-purified IgG antibody that recognizes human IkappaB-alpha. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection of human IkappaB-alpha protein.

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Features

  • Cat.#: 18669A
  • Target Name: Human IkappaB-alpha protein
  • Antigen: Human IkappaB-alpha N-terminal synthetic peptide
  • Application: WB
  • Target Entrez Gene ID: 4792

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1–2 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha, NFKBIA, NF-kappa-B inhibitor alpha, IKBA, MAD-3, NFKBI




 
 
Products
Cat. # Product Contents Size Price Units Select
18669A Anti-Human IkappaB-alpha(I037) Rabbit IgG Affinity Purify 100 ug $499.00
 

 

 
 

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