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Products >  Cell_Biology >  Cytokines >  Antibodies_H-T >  IL-2R_beta_CD122

Interleukin 2 Receptor Antibody: Anti-Mouse CD122/IL-2R beta Rat MoAb

The Interleukin 2 receptor (also known as IL-2R) is involved in signaling that affects T cell proliferation, and is comprised of three subunits: alpha, beta, and gamma. This monoclonal antibody (clone TM-beta 1) is an IL-2 receptor antibody. It binds to the IL-2 receptor beta subunit  and may be used for in vitro neutralization assays, as well as inhibiting the association between IL-2 and IL-2R beta subunit in vivo.

Although the IL-2R alpha and beta subunits can each bind IL-2 as monomers, the heterodimer complex formed through association of IL-2R alpha and beta subunits has a faster association rate and a slower dissociation rate for IL-2  versus either subunit by itself. Once the IL-2R alpha-beta dimer forms and binds IL-2, the gamma subunit is recruited. Activation of the JAK/STAT pathway, the MAP kinase pathway, and the PI3K pathway may then occur. IL-2 receptor beta is a type I membrane protein that binds IL-2 and associates with JAK1. IL-2R beta is also known as CD122, IL15RB, P75, and P70-75.

At-A-Glance Documents

Features

  • Cat.#: 10399F
  • Target Name: CD122/IL-2Rβ
  • Antigen: This antibody was generated by immunizing a rat with a rat transfectant cell line that highly expresses cDNA encoding murine IL-2R beta (Takana et al., 1991).
  • Application: neutralization (blocking) assays, inhibiting binding of IL-2 to IL-2R beta in vivo
  • Specificity: Reacts with mouse CD122 (IL-2R beta)
  • Target Entrez Gene ID: 3560
 

References

Generation of clone TM-beta 1:

  • Tanaka, T., et al.(1991) A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. J Immunol. 147(7):2222-8.

Examples of Use:

  • Sobolev, O., et al. (2009) Natural killer cells require selectins for suppression of subcutaneous tumors. Cancer Res. 69(6):2531-9.
  • Miki, T., et al. (2004) Parathyroid hormone-related protein (PTHrP) is responsible for production of bone metastasis, but not visceral metastasis, by human small cell lung cancer SBC-5 cells in natural killer cell-depleted SCID mice. Int. J. Cancer 108(4):511-5.
  • Nokihara, H., et al. (2000) Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice. Cancer Res. 60(24):7002-7.
  • Yano, S., et al. (1996) Novel metastasis model of human lung cancer in SCID mice depleted of NK cells. Int. J. Cancer 67(2):211-7.
  • Tanaka, T., et al. (1993) Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice. J. Exp. Med. 178(3):1103-7.

Storage

Store for up to 2 years at -20°C.

Form

Frozen in PBS. No additives included. Product is filter-sterilized (0.2 μm filter). Contains less than 0.3 EU/mg endotoxin.

Alternative names

Interleukin 2 Receptor, Beta; IL-2 Receptor Subunit Beta; CD122; IL-2R Subunit Beta; IL15RB; P75; Interleukin 15 Receptor, Beta; P70-75; High Affinity IL-2 Receptor Subunit Beta; High Affinity IL-2 Receptor Beta Subunit; IL-2RB; CD122 antigen.




 
 
Products
Cat. # Product Package Size Price # of Units Select
10399F Anti-Mouse CD122/IL-2Rbeta (TM-beta1) Rat IgG MoAb (Frozen) 0.5 mg $1,000.00
 

 


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