Interleukins are a group of cytokines that were originally identified in white blood cells (leukocytes). It is now known that interleukins are expressed in a wide variety of cells, and are involved in multiple cell signaling pathways. Interleukin 1 (IL-1) alpha and beta participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. IL-1 beta is produced primarily in activated macrophages by proteolytic cleavage of an inactive precursor by caspase 1. It also plays a role in memory functions and regulation of the central nervous system (CNS), as well as in cell proliferation, differentiation, and apoptosis. IL-1 beta acts through two main receptors that also bind IL-1 alpha. IL-1 beta is also known as catabolin, IL1B, and IL1F2.
This product is an affinity-purified IgG antibody that recognizes rat IL-1 beta protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of rat IL-1 beta protein.