CD25 is a component of the Interleukin 2 receptor (IL-2R). CD25 itself ,also known as IL-2R alpha, is a low-affinity receptor for IL2, but forms a high-affinity IL-2 receptor in association with CD122 and CD132 (beta and gamma subunits, respectively). CD25 is expressed in activated T cells and B cells. CD25 expression is used as a marker to identify regulatory T cells (Tregs or CD4+CD25+ cells), cells that modulate the immune response and prevent autoimmunity. Increased CD25 expression in serum has been observed in patients with adult T cell leukemia and patients with malignant lymphoma.
These products are anti-CD25 monoclonal antibodies. The antibodies were raised in mouse and can be used to detect human CD25 cells by Western blot, immunoprecipitation, and flow cytometry.