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Products >  Cell_Biology >  Cytokines >  Antibodies_D-G >  GRO_CINC-2_Rat

Anti-Rat GRO/CINC-2 Rabbit IgG Antibody

Rat cytokine-induced neutrophil chemoattractant-2 (CINC-2) protein is a member of the CXC family of chemokines. The rat CINC family members, including CINC-1, CINC-2-alpha, CINC-2-beta, and CINC-3, are homologous to human GRO/CXCL and mouse MIP-2/KC genes. Rat CINC-2-alpha and CINC-2-beta were originally identified as novel neutrophil chemoattractants in conditioned medium of granulation tissue obtained from carrageenan-induced inflammation. Mature CINC-2-beta is a 68 amino-acid protein that is generated by cleavage of a 32-residue signal peptide. CINC-2-alpha and CINC-2-beta differ by only three C-terminal residues. CINC-2-alpha and CINC-2-beta have similar chemotactic activity, and they contribute to neutrophil infiltration into inflammatory sites in rats. Other cell types that express CINC-2 proteins include activated macrophages and fibroblasts. Rat CINC-2 is also known as chemokine (C-X-C motif) ligand 3 (CXCL3) and GM160.

These products are affinity-purified IgG antibodies that recognize rat CINC-2 proteins. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection rat CINC-2 proteins.

At-A-Glance Documents

Features

  • Cat.#: 18275A, 18275B
  • Target Name: Rat CINC-2-alpha protein
  • Antigen: Rat CINC-2-alpha C-terminal synthetic peptide
  • Specificity: Does not cross-react with rat CINC-1, rat CINC-2-beta, or rat CINC-3
  • Application: WB
  • Target Entrez Gene ID: 171551

  • Cat.#: 18276A
  • Target Name: Rat CINC-2-beta protein
  • Antigen: Rat CINC-2-beta C-terminal synthetic peptide
  • Specificity: Does not cross-react with rat CINC-1, rat CINC-2-alpha, or rat CINC-3
  • Application: WB
  • Target Entrez Gene ID: 171551

  • Cat.#: 18277A
  • Target Name: Rat CINC-2-alpha and -beta proteins
  • Antigen: Rat CINC-2-alpha and -beta common N-terminal synthetic peptide
  • Specificity: Reacts with rat CINC-2-alpha and -beta; does not cross-react with rat CINC-1 or rat CINC-3
  • Application: WB
  • Target Entrez Gene ID: 171551

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 1 µg/mL (Cat.# 18275); 2–5 µg/mL (Cat.# 18276, 18277)

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing PBS. To use, reconstitute in 1.0 mL H2O.

Alternative names

Chemokine (C-X-C motif) ligand 3, CXCL3, cytokine-induced neutrophil chemoattractant-2, CINC-2, GM160




 
 
Products
Cat. # Product Package Size Price # of Units Select
18275A Anti-Rat GRO/CINC-2 alpha(C) Rabbit IgG Affinity Purify 10 ug $113.00 *
18275B Anti-Rat GRO/CINC-2 alpha(C) Rabbit IgG Affinity Purify 100 ug $499.00
18276A Anti-Rat GRO/CINC-2 beta (C) Rabbit IgG Affinity Purify 100 ug $499.00
18277A Anti-Rat GRO/CINC-2 alpha, 2 beta (N) Rabbit IgG Affinity Purify 100 ug $499.00
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