Rat cytokine-induced neutrophil chemoattractant-2 (CINC-2) protein is a member of the CXC family of chemokines. The rat CINC family members, including CINC-1, CINC-2-alpha, CINC-2-beta, and CINC-3, are homologous to human GRO/CXCL and mouse MIP-2/KC genes. Rat CINC-2-alpha and CINC-2-beta were originally identified as novel neutrophil chemoattractants in conditioned medium of granulation tissue obtained from carrageenan-induced inflammation. Mature CINC-2-beta is a 68 amino-acid protein that is generated by cleavage of a 32-residue signal peptide. CINC-2-alpha and CINC-2-beta differ by only three C-terminal residues. CINC-2-alpha and CINC-2-beta have similar chemotactic activity, and they contribute to neutrophil infiltration into inflammatory sites in rats. Other cell types that express CINC-2 proteins include activated macrophages and fibroblasts. Rat CINC-2 is also known as chemokine (C-X-C motif) ligand 3 (CXCL3) and GM160.
These products are affinity-purified IgG antibodies that recognize rat CINC-2 proteins. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection rat CINC-2 proteins.