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Products >  Cell_Biology >  Cytokines >  Antibodies_D-G >  GRO_Alpha_Human

Anti-Human GRO-alpha/MGSA (C) Rabbit IgG Antibody

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine subfamily. It was previously known as GRO1 oncogene, GRO-alpha, fibroblast secretory protein (FSP), and melanoma growth stimulating activity alpha (MSGA-alpha). CXCL1 is also known as neutrophil-activating protein 3 (NAP-3), growth-regulated alpha protein, C-X-C motif chemokine 1, SCYB1, and GROA. The rat homolog of human CXCL1 is known as CINC-1. CXCL1 is expressed by macrophages, neutrophils, and epithelial cells. It is secreted by human melanoma cells, has mitogenic properties, and is implicated in melanoma pathogenesis. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors. It also acts as a chemoattractant for neutrophils, and is involved in angiogenesis, inflammation, wound healing, and tumorigenesis. CXCL1 acts by signaling through the chemokine receptor CXCR2. Studies in mice have shown that CXCL1 decreased the severity of multiple sclerosis and may offer a neuroprotective function.

This product is an affinity-purified IgG antibody that recognizes human CXCL1 (GRO-alpha) protein. The antibody was raised in rabbit using a synthetic peptide, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human CXCL1 (GRO-alpha) protein.

At-A-Glance Documents

Features

  • Cat.#: 18356A
  • Target Name: Human CXCL1 (GRO-alpha) protein
  • Antigen: Human CXCL1 (GRO-alpha) C-terminal synthetic peptide
  • Specificity: Does not cross-react with human GRO-beta (CINC-3), IL-8, IP-10; does not cross-react with rat GRO/CINC-1, CINC-2-alpha, CINC-2-beta, or CINC-3
  • Application: WB, IHC
  • Target Entrez Gene ID: 2919

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL
  • Immunohistochemical techniques: 5–10 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing PBS. To use, reconstitute in 1.0 mL H2O (final concentration 100 µg/mL).

Alternative names

CXCL1, GRO1 oncogene, GRO-alpha, fibroblast secretory protein, FSP, melanoma growth stimulating activity alpha, MSGA-alpha, neutrophil-activating protein 3, NAP-3, growth-regulated alpha protein, C-X-C motif chemokine 1, SCYB1, GROA




 
 
Products
Cat. # Product Package Size Price # of Units Select
18356A Anti-Human GRO alpha /MGSA (C) Rabbit IgG Affinity Purify 10 ug $113.00 *
18356B Anti-Human GRO alpha /MGSA (C) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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