Cyclooxygenase (COX) is a membrane-bound enzyme that exists as two different isoforms: a constitutively expressed form (COX-1) and an inducible form (COX-2). Also known as prostaglandin endoperoxide H synthase 2 (PHS-2 or PGHS-2), PTGS2, PHS II, GRIPGHS, and Tis10, COX-2 converts arachidonic acid to prostaglandin endoperoxide H2 in a two-step reaction. Levels of COX-2 are elevated during inflammation. COX-2 expression is also upregulated in many forms of cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by both COX-1 and COX-2.
These products are affinity-purified IgG antibodies that recognize human or rat COX-2. The antibodies were raised in rabbit or mouse using synthetic peptides, and can be used for Western blot (WB) detection, immunohistochemical (IHC) detection, or immunoprecipitation (IP) of human or rat COX-2 protein.