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Products >  Cell_Biology >  Cytokines >  Antibodies_A-C >  COX-1_Human

Anti-COX-1 Antibody

Cyclooxygenase (COX) is a membrane-bound enzyme that exists as two different isoforms: a constitutively expressed form (COX-1) and an inducible form (COX-2). Also known as prostaglandin endoperoxide H synthase 1 (PHS-1 or PGHS-1), PTGS1, COX-3, PHS I, and PES-1, COX-1 converts arachidonic acid to prostaglandin endoperoxide H2 in a two-step reaction. COX-1 regulates angiogenesis in endothelial cells, and it is involved in cell signaling and maintaining tissue homeostasis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by both COX-1 and COX-2.

These products are affinity-purified IgG antibodies that recognize human or rat COX-1. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human or rat COX-1 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18511A, 18511B
  • Target Name: Human COX-1
  • Antigen: Human COX-1 synthetic peptide
  • Specificity: Specific to human COX-1. Does not cross-react with human COX-2 or rat COX-1.
  • Cat.#: 18521A, 18521B
  • Target Name: Rat COX-1
  • Antigen: Rat COX-1 synthetic peptide
  • Specificity: Specific to rat COX-1. Does not cross-react with rat COX-2 or human COX-1.

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Western blot: 2–5 µg/mL
  • Immunohistochemical techniques: 5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O.

Alternative names

prostaglandin endoperoxide H synthase 1, PHS-1, PGHS-1, PTGS1, COX-3, PHS I, PES-1




 
 
Products
Cat. # Product Package Size Price # of Units Select
18511A Anti-Human COX-1 (C24) Rabbit IgG Affinity Purify 10 ug $113.00 *
18511B Anti-Human COX-1 (C24) Rabbit IgG Affinity Purify 100 ug $499.00
18521A Anti-Rat COX-1 (C448) Rabbit IgG Affinity Purify 10 ug $113.00 *
18521B Anti-Rat COX-1 (C448) Rabbit IgG Affinity Purify 100 ug $499.00
* You must log in if you would like to purchase these products online, since the purchase of these products may be restricted depending on your account type. Researchers at not-for-profit accounts receive a limited use license with their purchase of the product. Researchers at for-profit accounts must obtain a license prior to purchase. For details please contact licensing@clontech.com.
 

 


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