Cyclooxygenase (COX) is a membrane-bound enzyme that exists as two different isoforms: a constitutively expressed form (COX-1) and an inducible form (COX-2). Also known as prostaglandin endoperoxide H synthase 1 (PHS-1 or PGHS-1), PTGS1, COX-3, PHS I, and PES-1, COX-1 converts arachidonic acid to prostaglandin endoperoxide H2 in a two-step reaction. COX-1 regulates angiogenesis in endothelial cells, and it is involved in cell signaling and maintaining tissue homeostasis. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by both COX-1 and COX-2.
These products are affinity-purified IgG antibodies that recognize human or rat COX-1. The antibodies were raised in rabbit using synthetic peptides, and can be used for Western blot (WB) detection or immunohistochemical (IHC) detection of human or rat COX-1 protein.