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Products >  Cell_Biology >  Cytokines >  Antibodies_A-C >  CIS3_SOCS-3_Human

Anti-Human CIS3/SOCS-3 Rabbit IgG Antibody

Suppressor of cytokine signaling 3 (SOCS-3) protein, encoded by the SOCS3 gene, is a member of the STAT-induced STAT inhibitor (SSI) family. It is also known as cytokine-inducible SH2 protein 3 (CIS3), CIS-3, SOCS3, SSI3, SSI-3, ATOD4, and Cish3. SOCS-3 is a cytokine-inducible downregulator of cytokine signaling. SOCS3 gene expression can be induced by cytokines such as IL6, IL10, and interferon-gamma. SOCS-3 protein can bind to, and inhibit the activity of, kinases that are involved in the JAK/STAT signaling pathway. Specifically, SOCS-3 is known to inhibit JAK2, as well as tyrosine kinase receptors such as gp130, LIF, erythropoietin, insulin, IL12, GCSF, and leptin receptors. SOCS-3 has been implicated in the negative regulation of fetal liver hematopoiesis and placental development.

These products are affinity-purified IgG antibodies that recognizes human SOCS-3. The antibodies were raised in rabbit using synthetic SOCS-3 peptides. They can be used for Western blot (WB) detection or immunohistochemical (IHC) detection (Cat.# 18391A, 18391B only) of human SOCS-3 protein.

At-A-Glance Documents Images & Data

Features

  • Cat.#: 18391A, 18391B
  • Target Name: Human SOCS-3 protein
  • Antigen: Human SOCS-3 C-terminal synthetic peptide
  • Clone: C204
  • Application: IHC, WB
  • Specificity: Cross-reacts with mouse SOCS-3
  • Target Entrez Gene ID: 9021

  • Cat.#: 18395A, 18395B
  • Target Name: Human SOCS-3 protein
  • Antigen: Human SOCS-3 N-terminal synthetic peptide
  • Clone: C005
  • Application: WB
  • Specificity: Cross-reacts with mouse SOCS-3
  • Target Entrez Gene ID: 9021

Applications

Recommended antibody concentration (the optimal concentration should be determined empirically):

  • Immunohistochemical techniques: 5 µg/mL
  • Western blot: 1–5 µg/mL

Storage

Lyophilized: stable 5 years at 2–8°C. In solution: stable 2 years at –20°C.

Form

Lyophilized from an antibody solution containing 1% BSA in PBS and 0.05% NaN3. To use, reconstitute in 1.0 mL H2O (final concentration, 100 µg/mL).

Alternative names

cytokine-inducible SH2 protein 3 (CIS3), CIS-3, SOCS3, SSI3, SSI-3, ATOD4, Cish3




 
 
Products
Cat. # Product Package Size Price # of Units Select
18391A Anti-Human CIS3/SOCS-3 (C204) Rabbit IgG Affinity Purify 10 ug $100.00
18391B Anti-Human CIS3/SOCS-3 (C204) Rabbit IgG Affinity Purify 100 ug $499.00
18395A Anti-Human CIS3/SOCS-3 (C005) Rabbit IgG Affinity Purify 10 ug $100.00
18395B Anti-Human CIS3/SOCS-3 (C005) Rabbit IgG Affinity Purify 100 ug $499.00
 

 



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